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Whole genome sequencing

Source BioScience provides whole genome analysis to support drug development using Illumina Sequencing technology. We are a UK preferred service supplier of this service. The technology can be used to identify new drug targets in a variety of diseases, and is quick and cost-effective.


Generate cost-effective data fast

Our high-throughput sequencing systems generate massive amounts per run at a fraction of the cost of conventional sequencing. Sequence analysis studies which usually take years can be completed in weeks. Low sample requirements mean that precious samples are preserved for further studies. Run by experienced molecular scientists, the Illumina platforms enable us to provide data from whole genome analysis rapidly.


Bioinformatics solutions


We offer both standard and advanced levels of bioinformatics analysis service for Illumina Genome Analyzer projects. Please note that novel algorithms for the analysis of next generation sequencing data are becoming available at a rapid rate. As a result, there is often a range of novel software packages from which to choose. In the following sections we describe some of the most popular bioinformatics solutions for a particular analysis type. However our bioinformatics team regularly investigate novel algorithms for their suitability to data analysis, and can offer advice on the particular application that will be most appropriate for your data.


Standard Bioinformatics Service

 Our Standard bioinformatics analysis service is currently included in the price of all sequencing projects. Using proprietary Illumina Pipeline software, this service includes:

  • Image analysis to identify individual clusters of reads
  • At each cycle of the sequencing run, using the relative intensity levels at each cluster to perform Base-Calling.
  • Generation of sequence reads with associated quality scores for each base
  • Generation of filtered read data, based on the per-base quality scores.
  • Generation of a customised Pipeline report, summarising run statistics and quality control analysis


Advanced Bioinformatics Service 

  • Alignment to Reference Sequence
    • Mapping of all reads to a specified reference genome
    • Statistic report detailing coverage, orientation of mapped reads, and numbers of unmapped reads
    • Summary of coverage available in both graphical and tabular format
  • Visualising sequence data within a genome browser
  • Resequencing and polymorphism detection
    • Mutation detection
    • Novel mutation discovery
    • Annotation of sequence polymorphism
    • Functional analysis of target genes