How We Can Support the Drug Development Pipeline

Target Validation

Source BioScience offers a comprehensive range of tests to validate new targets cost-effectively. Accurate validation of a potential target is crucial in the drug development process, and the role of the target in disease must be clearly defined to prevent failure later down the pipeline.

Source BioScience uses gene expression technologies as well as RNAi in cell culture to determine effects downstream reducing the risk of drug failure and facilitating go:no go decisions

Using PhenoFiler™, a novel platform which combines high throughput target profiling with proprietary bioinformatics analysis and with high-content siRNA knockdown phenotypic screening in cell cultures, Source BioScience can help to identify and validate new targets robustly.

Target Validation In Tissue

Source BioScience also understands the importance of validating potential drug targets in cells, so we have coupled genomic studies with validation of protein expression in tissue. 

Using quantitative IHC, FISH and image analysis profiling, supported by expert Pathologist review, we provide a comprehensive package of data to support target validation studies.

We can offer support and assay design for protein and novel target expression in a range of normal and diseased tissue

Including :

• IHC and novel marker assay development & Co-localisation studies
• ISH and molecular cytogenetics (FISH)
• Tissue microarrays & Biomaterials resource
• Quantitative Image analysis profiling with automated delineation
• Virtual Microscopy, web browser access
• Internal expertise in Phosphorylated  marker assay development