How We Can Support the Drug Development Pipeline

JAK

The Janus kinases or Jak kinases include four different enzymes (Tyk2, Jak1, Jak2, Jak3) that share significant structural homology with each other. They play an important role in interferon and cytokine signalling, and mutations in JAK are known to be associated with high relapse rates in certain malignancies such as acute lymphoblastic leukaemia or ALL. Since ALL is the second leading cause of cancer death in children, there has been a lot of interest in mutation analysis to predict response to treatment. JAK2 V617F mutation in exon 14 has been associated with myeloproliferative disorders associated with blood neoplasms.

Source BioScience offers JAK mutation analysis to support both clinical and research studies using rtPCR amplification targeting relevant regions of JAK2 or MPL, followed by amplicon sequencing and bioinformatics analysis to determine the presence of mutations.

For further information please contact us at:Pharma