How We Can Support the Drug Development Pipeline

Custom SNP genotyping

Description

Single Nucleotide Polymorphisms are bi-allelic, single base-pair changes between the DNA sequences of an individual. They can confer susceptibility or resistance to drug therapies and disease, and a number of SNPs are known to affect drug metabolism and clearance of drug from the body. As such, SNPs may cause toxic build up of drugs and abberant drug reactions. They may also be the cause of non response to a drug and are therefore important to detect to ensure that the best possible treatment is given to the patient. Source BioScience is a preferred service provider for Applied Biosystems TaqMan® and a UK reference lab for Roche AmpliChip® to support research studies and clinical trials. We also offer advice and recommendations for customised SNP projects too.

Illumina Custom SNP Genotyping Service

Introduction

Illumina Custom SNP Genotyping is performed on the Illumina GoldenGate Beadarray platform.

Assay Technology

The GoldenGate assay is used to interrogate 384 - 1536 SNPs simultaneously by using allele specific extension and ligation. The high level of multiplexing minimises the time and reagents required for processing. Researchers can select SNP loci of choice to form customer panels for targeted genotyping or an expanding selection of standard panels is also available including panels for cancer research.
Illumina goldengate custom panels

Source BioScience is an Illumina preferred service provider. We can also offer a range of other SNP genotyping services. Please click here for more information.

To discuss potential projects please contact us at:pharma